Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes.

On the contrary, the expression of pregnane X receptor (PXR or NR1I2 ) increased in HLCs compared with in hepatoblasts (although it did not reach statistical significance), as observed during later stages of liver development because of the direct binding of HNF4α ( Kamiya et al., 2003 ; Masuyama et al., 2001 ).

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