Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against <i>Bordetella pertussis</i> in a Mouse Model.

Front Immunol · 2022 · PMC9043693 · PMID 35493458

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did not reach statistical significanceno p-value reported

Moreover, compared with 2’,3’-cGAMP treatment, c-di-GMP treatment caused a slight increase in TNF-α production; however, the difference did not reach statistical significance ( Figure 2D ).

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