High levels of chromosomal aberrations negatively associate with benefit to checkpoint inhibition in NSCLC.

In fact, when patients treated in first and second line of therapy were taken together this association was highly significant (p=4.6 x 10 –4 , n=64).

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For this analysis, we stratified patients into tertiles, based on each immune cell type abundance, Only B cells reached statistical significance when comparing the lowest and highest tertiles ( figure 3C ) (log-rank test, p=0.043), although this comparison did not reach statistical significance when multiple test correction was applied (log-rank test, Q=0.421).

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