Understanding genetic risk factors for common side effects of antidepressant medications.

Commun Med (Lond) · 2021 · PMC9053224 · PMID 35602235

Europe PMC DOI

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did not reach statistical significanceno p-value reported

For example, MDD PRS was robustly associated with increased suicidality for venlafaxine, but evidence for association with other drugs did not reach statistical significance.

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failed to reach significanceno p-value reported

Nonetheless, genetic variants within these enzymes have failed to reach significance in recent genome-wide association studies on treatment resistance 27 and response 28 , suggesting that treatment outcomes might be more complex than previously thought.

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