Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.

Odds ratios showed a trend of skin and lymph node lesions responding more to D/T in BRAFi-naïve patients, compared to abdominal and muscle lesions ( Fig. 1D ).

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Thus, concentration differences found in tumors may be significant in clinically relevant dosage schemes and may influence treatment efficacy, particularly in less vascularized tumors where drug penetration issues are exacerbated.

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