Peripheral airways involvement in children with asthma exacerbation.

1 Historically, asthma was understood primarily the disease of large and medium airways, while the peripheral airways were considered almost insignificant for its development and control. 2 Nonetheless, over the past few years, there has been evidence of the peripheral airways involvement in the course of asthma, regardless of its severity. 3 , 4 Moreover, they can be the main site of airflow limitation in patients with asthma. 5 Clin

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The median of exhaled NO values in children with asthma exacerbation was higher than in children with stable asthma, but the difference did not reach statistical significance. 3.3.

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