Pharmacological interventions enhance virus-free generation of <i>TRAC</i>-replaced CAR T cells.

Mol Ther Methods Clin Dev · 2022 · PMC9062427 · PMID 35573047

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showed a trendno p-value reported

Finally, CD19-CAR T cells generated by optimized knockin of the CD19-CAR into TRAC showed a trend toward superior in vivo performance in a xenograft pre-B lymphoblastic leukemia mouse model compared with LV-transduced counterparts.

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