The CLIP-170 N-terminal domain binds directly to both F-actin and microtubules in a mutually exclusive manner.

J Biol Chem · 2022 · PMC9062740 · PMID 35283190

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quite significantno p-value reported

However, the concentration of actin at the cell cortex is extremely high (>300 μM) ( 29 , 30 ), which makes weak F-actin affinities potentially quite significant in the cortex regions.

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