Barely Significant
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The Paget's disease of bone risk gene PML is a negative regulator of osteoclast differentiation and bone resorption.

Dis Model Mech · 2022 · PMC9066519 · PMID 35229101

2
hedged sentences
0.0500
closest p · 1.0× alpha
0.0900
boldest claim

The sentences

of borderline significanceP =0.05actually significant
In addition, expression of Col1a1 was higher in osteoblasts from Pml −/− compared with wild type but this was of borderline significance ( P =0.05; Fig. 5 D).

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did not reach statistical significanceP =0.09so close (0.05 < p ≤ 0.1)
There was also a trend for higher bone formation rate per bone surface (BFR/BS) in Pml −/− mice compared with wild type but this did not reach statistical significance ( P =0.09; Table 1 ).

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