S1B ) with an obvious trend of comparatively higher H3K9me3 read counts in compartment B than in A ( Fig. 1 B).
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H3K9 trimethylation in active chromatin restricts the usage of functional CTCF sites in SINE B2 repeats.
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We detected a total of 40,893 CTCF peaks in wild-type and SETDB1-depleted macrophages, with 78% of them in compartment A, and a clear trend toward increased occupancy in SETDB1-depleted macrophages ( Fig. 3 C; Supplemental Table S6 ).