Circulating immune-complexes and complement activation through the classical pathway in myeloperoxidase-ANCA-associated glomerulonephritis.

Increase in the serum levels of C5a and C5b-9, and their significant correlation with CICs in patients with MPO-AAGN Generally, both serum C5a levels and serum C5b-9 levels were significantly higher in MPO AAGN (G1 + G2) patients than in the healthy controls (C5a: 47.9[33.8–57.9] vs 12.3[9.4–16.7], p < 0.001; C5b-9: 6,162[4,071–9,102] vs 853[521–1,513], p < 0.001), and they also tended to be higher in the G1 group than in the G2 group, although the difference in both C5a and C5b-9 levels between G1 and G2 did not reach statistical significance ( Figure 2 ).

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