Pulsed electromagnetic fields inhibit mandibular bone deterioration depending on the Wnt3a/β-catenin signaling activation in type 2 diabetic db/db mice.

Wnt antagonist or Wnt3a silencing blunts PEMF-induced acceleration of differentiation and proliferation of primary osteoblasts in db/db mouse mandible The primary osteoblasts isolated from db/db mice treated with Wnt antagonist DKK1 exhibited trend with minor decrease in cellular proliferation (MTT assays) and differentiation (alkaline phosphatase staining and differentiation-related gene expression) as compared with the osteoblasts from db/db mice without DKK1 treatment, but these changes did not reach statistical significance (Fig. 5 A–F).

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