Enhanced C/EBPβ function promotes hypertrophic versus hyperplastic fat tissue growth and prevents steatosis in response to high-fat diet feeding.

However, no significant changes were measured in LAP/LIP expression ratios, despite an overall trend towards a lower LAP/LIP ratio on HFD in wt females ( Figure 8D, E ).

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In contrast to the males, female Cebpb ΔuORF mice showed reduced fat accumulation in the subcutaneous fat depot upon HFD compared to wt mice, and the visceral fat depot showed a trend towards a reduced fat storage although this difference was not statistically significant ( Figure 1F and G ).

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