Association of genetic polymorphisms with psychological symptoms in cancer: A systematic review.

Another FKBP5 SNP, rs1360780, also showed a trend for a genotype by time interaction with depression severity of the patients ( P ​= ​0.075), where the increase in depression severity over time among the homozygous wild type patients was reported to be smaller, compared to those having at least one copy of the rare allele.

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However, the −251 ​T ​> ​A polymorphism of IL-8 showed a marginally significant level of association with depression, where the possession of the rare allele conferred a lowered risk of severe depression.

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