IL-36 signalling enhances a pro-tumorigenic phenotype in colon cancer cells with cancer cell growth restricted by administration of the IL-36R antagonist.

Oncogene · 2022 · PMC9076531 · PMID 35365751

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Whilst HT29 cells showed a trend of increased invasion following IL-36R agonist stimulation, IL-36β and IL-36γ showed a significant increase in cellular invasion in CT26 cells when compared to the untreated control and also IL-36α (Fig. 4E ).

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