Barely Significant
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NHC-BIAN-Cu(I)-Catalyzed Friedländer-Type Annulation of 2-Amino-3-(per)fluoroacetylpyridines with Alkynes on Water.

J Org Chem · 2022 · PMC9087358 · PMID 35394784

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a clear trendno p-value reported
Apart from observing a significant difference of around 5 kcal/mol that explains the higher conversions for the copper catalytic systems, results do not follow a clear trend in any of the metal catalyst series.

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