nearly significantp -value < 0.056
The decreased circulatory glutamine levels might be related to active glutaminolysis in EM patients. It is important to mention here that both the proline and glutamine levels have been estimated with respect to formate (as an internal reference), and possibly, this may have impacted the quantitative profiles of these metabolites, rendering a nearly significant change in the glutamine levels between the EM and NC groups ( p -value < 0.056, Figure 2 B).