TREX1 KO mice also showed a similar trend, though it did not reach statistical significance (Fig. 2E ).
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Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells.
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We also investigated the levels of Th17 cells and observed a marginal elevation of IL‐17 producing cells in spleen of TREX1 D18N mice that was close to significance, however, no significant differences were observed in the LNs and in FX1‐treated animals (See Fig. 4 below and Supporting information Fig.