Use of antisense oligonucleotides to target Notch3 in skeletal cells.

Notch3 6691-TAATGA mutant mRNA was expressed in tibiae only from Notch3 em1Ecan mice, and it was suppressed by ~50% following the administration of Notch3 ASOs for 4 weeks, although the effect did not reach statistical significance ( Fig 4 ).

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