IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function.

While population average neutrophil counts ( Figure 3G ) were higher in the anti-ACE2–positive group (6.68 K/mm 3 ) than in the anti-ACE2–negative group (4.95 K/mm 3 ), these results did not reach statistical significance ( P = 0.10).

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