GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases.

At this point, we could find differences close to significance in total body bioluminescence, emitted by luciferase-expressing cancer cells, between mice treated with T22-PE24-H6 and buffer-treated mice ( Figure 6B ).

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Moreover, when repeatedly administering low doses of T22-PE24-H6 in the highly metastatic cell-derived orthotopic model, we observed a significant 2-fold reduction in the number of lymphatic and hematogenous metastatic foci and a decreasing trend in the primary tumor and metastatic foci size.

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There was also a trend of a reduction of the mean number of peritoneal metastatic foci in T22-PE24-H6-treated mice (similar to the reduction in bioluminescence emission by peritoneal metastases described above); however, it did not reach statistical significance.

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