Klotho in Osx<sup>+</sup>-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair.

Signal Transduct Target Ther · 2022 · PMC9090922 · PMID 35538062

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22 , 26 Moreover, deletion of Klotho in long bone mesenchymal stem cells ( Prx1Cre;KL fl/fl ), as well as in osteocytes ( Dmp1Cre;KL fl/fl ), both showed a trend towards reduced osteoclastic resorption parameters. 11 , 27 Overall alveolar bone volume in OsxCre;KL fl/fl mice was relatively increased.

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