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miR-23b-3p rescues cognition in Alzheimer's disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways.

Mol Ther Nucleic Acids · 2022 · PMC9092887 · PMID 35592504

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However, the result did not reach statistical significance. miR-23b-3p mimics also inhibited apoptosis in normally cultured APPswe cells without copper treatment, as demonstrated by a reduction in propidium iodide (PI)-stained cells in the immunofluorescence assay ( Figure 2 C) and a reduction in apoptotic ratios in flow cytometry ( Figures 2 D and 2E; p < 0.05, p < 0.01 versus NCM).

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