Detailing the effects of polypharmacy in psychiatry: longitudinal study of 320 patients hospitalized for depression or schizophrenia.

The observed outcome differences between polypharmacy and monotherapy did not reach statistical significance ( p = 0.1559).

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This splitting of the multiplex side effect profiles into several intrinsic sub-clusters not only affirmed considerable differences between the sub-clusters in terms of their occurrence, but also revealed some highly significant differences between the diagnostic groups although the majority of side-effect clusters were very similar across diagnoses.

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