Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection.

Furthermore, breakthrough infection donors exhibited higher serum IgA binding titers to both WT and BA.1 RBDs relative to uninfected/vaccinated donors, although this did not reach statistical significance for WT RBD due to the increased variability in IgA responses and small sample sizes ( Fig. 1C ).

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