Acute Hypoxia Alters Extracellular Vesicle Signatures and the Brain Citrullinome of Naked Mole-Rats (<i>Heterocephalus glaber</i>).

Overall, PAD2 showed no significant changes, with a possible trend for reduced levels (albeit high variability was observed between samples, not reaching statistical significance, and one outlier was observed), and PAD4 protein levels were statistically significantly reduced in the hypoxia-challenged brains ( p = 0.0031), whereas PAD1, PAD3, and PAD6 levels showed an overall trend for elevation in the hypoxia-challenged brains (albeit not reaching statistical significance and with considerable individual variability observed).

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This is further reflected in changes of PAD isozyme expression in the hypoxic brains, which showed a trend for elevation of some PADs (PAD1, PAD3, and PAD6) and a trend for reduction in other PADs (PAD2 and PAD4) under hypoxic conditions, further indicating a possible selective role for PAD-isozymes and associated isozyme-specific deimination in hypoxia response and tolerance.

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