Prenatal Choline Supplementation Alters One Carbon Metabolites in a Rat Model of Periconceptional Alcohol Exposure.

Nutrients · 2022 · PMC9100923 · PMID 35565848

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0.0600

closest p · 1.2× alpha

0.0900

boldest claim

The sentences

did not quite reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

Other components of the methionine cycle were also altered, with prenatal choline resulting in an increase in methionine in both males and females ( Supplemental Figure S7A,E ), an increase in B6 in males only ( Supplemental Figure S7B,F ), and an increase in Hcy ( Supplemental Figure S7C,G ), although in male plasma this did not quite reach statistical significance ( p = 0.06).

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did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

A similar pattern was seen for Mtr , although the interaction term did not reach statistical significance ( p = 0.09, Figure 5 B).

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