a significant trendP = 0.906
Impact of Extended Lymphadenectomy For those with node-negative and node-positive diseases, the curves of the hazard ratios (HRs; OS) of each ELN count (>16 nodes) compared with 16 ELNs (as a reference) were smoothed using the LOWESS technique and are shown in Figure 5 and Figure 6 , respectively; however, they failed to demonstrate a significant trend of survival benefit that favored a more extensive lymphadenectomy (HR, 1.001; 95% CI, 0.989 to 1.012; P = 0.906; and HR, 0.996; 95% CI, 0.985 to 1.006; P = 0.405, respectively).