Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

Nat Commun · 2022 · PMC9106650 · PMID 35562349

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 1E−35actually significant

Of the top 100 proteins highest in the s11 subtype, 58 were among the top 10% brain tissue-specific genes, a highly significant overlap ( p < 1E−35, one-sided Fisher’s exact test).

also in 132,142 other papers

nominally significantno p-value reported

Even in instances of nominally significant proteins that moderately exceed chance expectations by estimated FDR, the top proteins may still contain molecular information representing real biological differences.

also in 7,732 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.