slightly significantP = 0.05
Overall, the summarized estimate of effect size indicated a slightly significant difference between the two groups (RR = 0.82, 95% CI 0.67 to 1.00, P = 0.05, Figure 7(a) ), which favored the third-generation PVAS, with moderate heterogeneity ( I 2 = 44%, P = 0.08).