APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.

Acta Neuropathol · 2022 · PMC9107450 · PMID 35471463

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More interestingly, we found the amount of insoluble APOE in FA fractions was strongly correlated with the maximum RT-QuIC ThT signals (OR = 1.09, p < 0.001), with a similar, though slightly weaker, nominally significant ( p < 0.05) association observed when adjusting for a number of APOE4 alleles (OR = 1.07, p = 0.01, Table 6 ).

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