Barely Significant
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Paired primary and metastatic lesions of patients with ipilimumab-treated melanoma: high variation in lymphocyte infiltration and HLA-ABC expression whereas tumor mutational load is similar and correlates with clinical outcome.

J Immunother Cancer · 2022 · PMC9109111 · PMID 35550553

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a clear trendno p-value reported
Although for metastatic tumors there was a clear trend, the correlation was not significant which could be due to the small sample size.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.