A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules.

The highly significant networks, represented in the Tier 1 and Tier 2 modules which we presented in more detail in this study, capture many of these pathophysiological aspects of ALS biology, in particular oxidative stress and proteostasis, but also other plausible biological mechanisms with less research focus such as lipid metabolism (module 93) and neuron specific functions such as neurotransmission and synapse (module 128).

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This indicates that the overlap matrix in Fig 4 is not just driven by a generic overlap in literature between ALS and the top 50 diseases, but it represents a clear trend towards the overlap with a specific subset of diseases.

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