Endocannabinoid Modulation Using Monoacylglycerol Lipase Inhibition in Tourette Syndrome: A Phase 1 Randomized, Placebo-Controlled Study.

Although the mean [90% CI] TWA overall treatment effects versus placebo of −0.7 [−2.0, 0.5] for MRVS and −1.1 [−2.7, 0.5] for YGTSS-TTS failed to reach statistical significance, analysis of each time point revealed that the treatment effect on YGTSS-TTS was significant versus placebo at the 8 h time point (−3.0 [−5.4, −0.6], p=0.04) and statistically significant mean placebo-adjusted reductions were also observed for YGTSS-MTS at 4 hours post-dose (−1.5 [−2.8, −0.3], p=0.05).

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The effects on tics, premonitory urges, and psychiatric comorbidities were evaluated using a variety of scaled approaches at different time points before and after treatment. Results All scales showed an overall trend of tic reduction, with two out of three tic scales (including the Total Tic Score of the Yale Global Tic Severity Score) showing a significant effect of a single dose of Lu AG06466 versus placebo at various timepoints.

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