Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion.

Commun Biol · 2022 · PMC9110401 · PMID 35577844

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In nlrc3l mutants, the DDC, which has descending projections to the motor circuits, showed a significant reduction in TH protein level alongside a modest and nearly significant TH reduction in the LC (Fig. 6e, f ), but there was no change in the other brain regions analyzed.

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