The Effect of Hyperoxemia on Neurological Outcomes of Adult Patients: A Systematic Review and Meta-Analysis.

Although our results did not achieve significance, they showed a trend toward harm from hyperoxemia in patients post ROSC.

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Grouping studies based on inclusion of hypoxemic patients in their controls, we found a significant association in studies without hypoxemia in controls but only a borderline significant association in studies including hypoxemia in controls (Supplementary Fig. 3b).

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Lastly, in subgroup analysis by ventilation status, hyperoxemia showed a nonsignificant trend toward poor neurological outcome in definitely ventilated patients and the unassessable ventilation status group, whereas a significant association was found in probably ventilated patients, and in mixed ventilated and nonventilated patients (Supplementary Fig. 4b).

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