Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus.

We also found that IGHV4-39 , IGHD2-2 , IGHD3-3 and IGHJ6 , which we find are expanded in CV19 across multiple B cell partitions, only have significantly increased expression in the under 50s and not the over 60s; IGHV4-34 appeared increased in both age groups in the IgG1 partition, but did not reach statistical significance ( Figure 4C ).

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