Scaffold stability and P14' residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4.

Biosci Rep · 2022 · PMC9112662 · PMID 35485437

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closest p

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quite significantno p-value reported

However, the Inf4_F10P+N12I and Inf4_F10P+V14M double mutants showed quite significant reductions in inhibitory potential, with IC 50 values of 22.8 ± 4.7 and 42.1 ± 8.4 nM, respectively.

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