Fra-2 overexpression upregulates pro-metastatic cell-adhesion molecules, promotes pulmonary metastasis, and reduces survival in a spontaneous xenograft model of human breast cancer.

At necropsy excised control primary tumours were significantly smaller than Fra-2 cl 1 tumours, whereas the difference to cl 2 tumours did not reach statistical significance (control mean tumour weight = 0.67 g, Fra-2 cl 1 mean tumour weight = 1.63 g, Fra-2 cl 2 mean tumour weight = 0.87 g; control vs Fra-2 cl 1 p = 0.018; control vs Fra-2 cl 2 p = 0.513) (Fig. 1 b).

also in 111,027 other papers