CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate.

In electrocorticogram analysis, the median of the poly spike and wave discharges frequency was slightly higher in the primary somatosensory cortex forelimb region of Cux2 (−/−) than WT mice, however the difference did not reach statistical significance (data not shown).

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