The anti-CD19 CAR-Ts, axicabtagene ciloleucel and lisocaptagene maraleucel, show significant improvement in PFS and a strong trend in OS (significant in univariate analysis) in two Phase III clinical studies in high-risk r/r LBCL compared with salvage therapy (ST) followed by auto-HCT [ 93 , 94 ].
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Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022.
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