Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.

Sci Rep · 2022 · PMC9120074 · PMID 35589863

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nominally significantno p-value reported

It is interesting to note that the base GWAS reported a nominally significant genetic correlation between schizophrenia and AD 7 .

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borderline significantno p-value reported

The 10 loci that remained non-replicated included 3 that were borderline significant in our GWAS ( CLNK/HS3ST1 , BZRAP1-AS1 , and CASS4 ) and 7 that were not close to genome-wide significance ( LCORL , ANKRD31 , NME8 , NDUFAF6 : TP53INP1 , PLCG2 , CD33 , and APP ).

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highly significantno p-value reported

We also show highly significant genetic correlations with multiple health-related outcomes that provide insights into prodromal symptoms and comorbidities.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.