ADAM10 facilitates rapid neural stem cell cycling and proper positioning within the subventricular zone niche via JAMC/RAP1Gap signaling.

Neural Regen Res · 2022 · PMC9120697 · PMID 35535899

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As above, inhibition of ADAM10 activity with GI 254023X increased adhesion of WT treated cells to a laminin substrate, while treatment with the Rap1 activator showed a trend towards an increase in adhesion when plated on laminin ( Figure 9B ).

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