Although the risk of major bleeding was numerically higher with DOACs, this difference did not reach statistical significance (RR, 1.17, 95%CI, 0.82–1.67; p = 0.39; I 2 = 12%; Fig. 1 ).
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Direct oral anticoagulant versus low molecular weight heparin for the treatment of cancer-associated venous thromboembolism: 2022 updated systematic review and meta-analysis of randomized controlled trials.
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0.3900