Mass spectrometry-based proteomics identify novel serum osteoarthritis biomarkers.

Arthritis Res Ther · 2022 · PMC9125906 · PMID 35606786

Europe PMC DOI

hedged sentences

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

a trend toward significancep =0.064so close (0.05 < p ≤ 0.1)

Data showed that statistical difference was reached when OA was compared to controls for FBN1 ( p =0.044), and VDPB ( p =0.022), and a trend toward significance for SERPINF1 ( p =0.064) (Fig.S 1 ).

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a strong trendno p-value reported

2 B), CRP, CRTAC1, LYZ, PTGDS, FBN1, IGHV3-35, KHSRP, and S100A9 were all upregulated in the OA-non-obese; PTGDS was included in the upregulated proteins as the q -value ( q =0.054) showed a strong trend towards significance.

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a numerical trendno p-value reported

Validation experiments showed that there was a numerical trend toward significance when OA was compared to controls.

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