CCR5 activation and endocytosis in circulating tumor-derived cells isolated from the blood of breast cancer patients provide information about clinical outcome.

Breast Cancer Res · 2022 · PMC9125938 · PMID 35606863

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hedged sentences

0.0021

closest p · 0.0× alpha

0.0800

boldest claim

The sentences

highly significantp = 0.0021actually significant

Overall, it was determined that the presence of an average number ≥ 10 CCR5 pools on CAMLs was a highly significant predictor of worse PFS and OS (PFS HR = 4.5, CI95% 1.8–10.8, p = 0.0021 and OS HR = 3.7, CI 95% 1.4–9.6, p = 0.0137).

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approaching significancep = 0.0800so close (0.05 < p ≤ 0.1)

4 e-f), it was determined that a threshold of an average of ≤ 5 CCR5 pools was approaching significance as an indicator of worse PFS, but not OS (PFS HR = 2.5, CI 95% 1.0–6.2, p = 0.0800 and OS HR = 2.1, CI 95% 0.8- 5.5, p = 0.2045) (Additional file 1 : Figs.

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