Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2.

Two other regions showed nominally significant replication p values in AA ( SEMA3C , p = 0.046) and HISP ( ISX , p = 0.014), but not in NHW.

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Thus, there are now two studies using independent datasets, sequencing techniques and different AD-related outcome phenotypes converging on highly significant rare-variant association signals in DTNB , emphasizing the likely crucial – and hitherto unrecognized – role of this gene in AD pathogenesis.

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