Lifespan extension with preservation of hippocampal function in aged system x_c^--deficient male mice.

1A ) and a strong trend for an increased maximum lifespan (Fig. 1B ), despite an increased cystine/cysteine ratio in the plasma of aged xCT −/− mice, compared to age-matched xCT +/+ mice and adult mice (Fig. 1C–E ).

also in 5,725 other papers

Comparable to the observations made in the plasma, the lactate/pyruvate ratio showed a borderline significant increase in the aged hippocampus of both genotypes (Supplementary Fig. 7E–G ).

also in 11,409 other papers