Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart Failure.

8 However, RAAS inhibitors may incompletely block the effects of RAAS mediators and paradoxically increase the production of renin, fueling a phenotype of “aldosterone breakthrough.” 44 , 45 In this analysis, we found that higher aldosterone levels may be associated with less sodium excretion, but estimates did not reach statistical significance in the adjusted models.

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