Notably, virus DNA levels were reduced by less than 30% in HCMV-infected NHDFs treated with eIF3d-siRNA compared to control, non-silencing siRNA, and this difference (p > 0.05) did not reach statistical significance ( Figure 2E ).
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An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.
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